🌐 English Site
客服热线：400-620-6333
  • 联系我们
  • 技术支持
  • 订单查询
  • 登录
  • 注册
切换导航
购物车
搜索
现货产品当日发货
高级搜索
快速下单 SDS / CoA 结构搜索 大包装与定制
菜单
登录
྾
224,000+ 科研产品 · 三重ISO认证 · 每个产品均提供COA和SDS · 现货产品当日发货

Recombinant Human GDF8 / Myostatin Protein

货号: rp156335
COA
有货
级别和纯度: 无动物源 ? 无动物源（Animal Free）—— 不含动物源成分生产，降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 PBS Only ? 仅 PBS 配方 —— 以磷酸盐缓冲液供应，不含其他添加剂。当需要不含稳定剂/载体的洁净 PBS 缓冲液时使用。 ≥95%(SDS-PAGE) 见COA
Accession #
O08689
蛋白标签
C-His
表达系统
HEK293
内毒素水平
<1.0 EU/μg
生物活性
Immobilized Recombinant human GDF8/Myostatin protein (rp156335) at 1.0 μg/mL can bind Domagrozumab (anti-GDF8) (Ab175511) with the EC50 of 33.4 ng/mL.
★
规格
库存
价格
数量
10μg
rp156335-10μg
期货 Stock Image
¥1,169.90
50μg
rp156335-50μg
期货 Stock Image
¥3,489.90
100μg
rp156335-100μg
期货 Stock Image
¥5,589.90
1mg
rp156335-1mg
期货 Stock Image
¥29,639.90
请输入您要添加的产品数量
大包装 / 定制
♡ 收藏夹 ⇅ 比较 ⎙ 打印页面
SDS
安全数据
COA
分析证书
Data Sheet
产品数据
Spec Sheet
规格说明
大包装询价 收藏夹
Recombinant Human GDF8 / Myostatin Protein
规格 储存与运输 图片 技术文档 高级数据 质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章 溶液计算器
🧪
为什么选择此级别

ActiBioPure™,His标签,PBS Only,无动物源,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

规格

产品名称
Recombinant Human GDF8 / Myostatin Protein
别名
重组人GDF8 / Myostatin蛋白 | 重组人肌肉生长抑制素蛋白 | 重组人生长/分化因子 8蛋白
英文别名
GDF8 | GDF-8 | GDF8growth differentiation factor 8 | growth/differentiation factor 8 | MSLHP | MSTN | Myostatin
规格或纯度
无动物源, 无载体, 生物活性, ActiBioPure™, His标签, PBS Only, ≥95%(SDS-PAGE), 见COA
生化机理
GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF-8 / Myostatin / MSTN is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Experiments in mice have improved that GDF-8 / Myostatin / MSTN is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking Myostatin encoding gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. GDF-8 / Myostatin / MSTN is also expressed in the early phases of fracture healing, and GDF-8 / Myostatin / MSTN deficiency leads to increased fracture callus size and strength. Together, these data suggest that GDF-8 / Myostatin / MSTN has direct effects on the proliferation and differentiation of osteoprogenitor cells and that GDF-8/Myostatin/MSTN antagonists and inhibitors are likely to enhance both muscle mass and bone strength. Post-translational: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
生物活性
Immobilized Recombinant human GDF8/Myostatin protein (rp156335) at 1.0 μg/mL can bind Domagrozumab (anti-GDF8) (Ab175511) with the EC50 of 33.4 ng/mL.
表达系统
HEK293
种属
人(Human)
氨基酸
1-376​ aa
序列
MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCSHHHHHH​
蛋白标签
C-His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
40.9 kDa
SDS-PAGE
13.8 & 37.2 & 50.3 kDa, under reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片

Recombinant human GDF8 / Myostatin protein (rp156335) - ELISA
Immobilized Recombinant human GDF8 / Myostatin protein (rp156335) at 1.0 μg/mL can bind Domagrozumab (anti-GDF8) (Ab175511) with the EC50 of 33.4 ng/mL.

Recombinant human GDF8 / Myostatin protein (rp156335) - SDS-PAGE
3 μg/lane of Recombinant human GDF8 / Myostatin protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 13.8 & 37.2 & 50.3 kDa under reducing.

This protein carries a polyhistidine tag at the N-terminus. The protein migrates as 13.8 kDa, 37.2 kDa and 50.3 kDa when calibrated against Protein Marker under reducing (R) condition (SDS-PAGE), speculated as mature GDF-8, propeptide and latent GDF-8 respectively due to glycosylation.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number) 证书类型 货号
ZJ25F0319616 分析证书 rp156335
ZJ25F0319615 分析证书 rp156335
ZJ25F0319614 分析证书 rp156335
技术文档和文章
GDF家族细胞因子的结构特征、信号通路与功能分化机制
目录： 技术文章
探索主题:
SMAD BMP BMPR TGF-β超家族 GDF5 GDF8 GDF9 GDF11 GDF15 ActRIIB GDF家族 生长分化因子 细胞分化 组织发育
Structural Features, Signaling Pathways, and Functional Differentiation Mechanisms of GDF Family Cytokines
目录： 技术文章
探索主题:
SMAD BMP BMPR TGF-β superfamily GDF family growth differentiation factor GDF5 GDF8 GDF9 GDF11 GDF15 ActRIIB cell differentiation tissue development
溶液计算器
隐私政策 使用条款 Cookie政策 销售条款 销售政策
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。