Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
生物活性
Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED50 for this effect is 2-8 ng/mL.
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20~-80℃(1年);复溶后建议分装,避免反复冻融。
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Recombinant Human IL-34 Protein (rp168119) - Protein Bioactivity
Measured in a cell proliferation assay using human peripheral blood mononuclear cell. The ED50 for this effect is 4.327 ng/mL.
Recombinant Human IL-34 Protein (rp168119)- SDS-PAGE
2 μg/lane of Recombinant Human IL-34 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 30 - 38 kDa.