Small inducible cytokine A4 | CCL4 | Macrophage inflammatory protein 1-beta | MIP-1- beta | MIP-1-beta(1-69) | T-cell activation protein 2 | ACT-2 | PAT 744 | H400 | SIS-gamma | Lymphocyte activation gene 1 protein | LAG-1 | HC21 | G-26 T-lym
规格或纯度
无载体,生物活性,ActiBioPure™,高性能,≥90%(SDS-PAGE),见COA
生化机理
CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. CCL4 may be a new molecular therapeutic target for inhibition of lymphangiogenesis and metastasis in OSCC. CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. CCL4 can enhance the recruitment of preosteoclasts to bone in the early stage, and the reduction of CCR5 promotes osteoclastogenesis when RANKL is prevalent.
Post-translational: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
生物活性
Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0 - 20.0 ng/mL.
14.1 & 18.7 kDa, under reducing conditions; 12.3 & 17.8 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human CCL4/MIP-1 beta Protein (rp170426) - SDS-PAGE
3 μg/lane of Recombinant Human CCL4/MIP-1 beta Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the bands at 14.1 & 18.7 kDa under reducing conditions and 12.3 & 17.8 kDa under non-reducing conditions.
CCL4/MIP-1 beta Protein belongs to the chemokine family, and these proteins often form dimers or multimers through disulfide bonds (Uniprot ID: P13236).
Recombinant Human CCL4/MIP-1 beta Protein (rp170426) - Protein Bioactivity
Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/mL.
ZJ26F0131603
危险品化学品经营许可证（带存储）