Purity: ≥90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
规格
产品名称
Recombinant Human MMP-2 Protein
别名
重组人MMP-2蛋白 | 重组人MMP-2蛋白
英文别名
72 kDa gelatinase | CLG4 | CLG4A72 kDa type IV collagenase | collagenase type IV-A | EC 3.4.24 | EC 3.4.24.24 | Gelatinase A | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase) | matrix metalloproteinase 2 (gelatinase A,
规格或纯度
无动物源, 无载体, 生物活性, His标签, ≥90%(SDS-PAGE)
生物活性
Immobilized Recombinant Human MMP-2 Protein (rp181213) at 1.0 μg/mL can bind MMP2 Mouse mAb (Ab115657) with the EC50 of 23.04 ng/mL
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human MMP-2 Protein (rp181213) - ELISA Immobilized Recombinant Human MMP-2 Protein (rp181213) at 1.0 μg/mL can bind MMP2 Mouse mAb (Ab115657) with the EC50 of 23.04 ng/mL.
Recombinant Human MMP-2 Protein (rp181213) - SDS-PAGE 2 μg/lane of Recombinant Human MMP-2 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 70.7 kDa.
ZJ24F0606742
危险品化学品经营许可证（带存储）