c-Jun N-terminal kinase 1 | EC 2.7.11 | EC 2.7.11.24 | JNK1 alpha protein kinase | JNK1 beta protein kinase | JNK1 | JNK1JNK1A2 | JNK-46 | JUN N-terminal kinase | MAP kinase 8 | MAPK 8 | MAPK8 | mitogen-activated protein kinase 8 isoform JNK1 alpha1 | mit
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥85%(SDS-PAGE),见COA
生化机理
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation, and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. Genetic analysis indicates that the effects of JNK1 can be separated from the effects of JNK1 on obesity. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in hypoxic cellular damage. JNK1 protein might be an attractive target for anti-hypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.
Post-translational: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2. May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1. Phosphorylated form is more concentrated at synapses than none-phosphorylated.
生物活性
Immobilized Recombinant Human JNK1 Protein (rp183743) at 1.0 μg/mL can bind Recombinant JNK1 Antibody (Ab111518) with the EC50 of 40.4 ng/mL.
49.1 kDa, under reducing conditions; 49.1 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 1mM DTT, 20% Glycerol, pH 7.4.
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human JNK1 Protein (rp183743) - ELISA Immobilized Recombinant Human JNK1 Protein (rp183743) at 1.0 μg/mL can bind Recombinant JNK1 Antibody (Ab111518) with the EC
₅₀
of 40.4 ng/mL.
Recombinant Human JNK1 Protein (rp183743) - SDS-PAGE 3 μg/lane of Recombinant Human JNK1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 49.1 kDa.
ZJ24F1114285
危险品化学品经营许可证（带存储）