Protein Function: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
规格
产品名称
Recombinant Human NLRP3 Protein
别名
重组人NLRP3蛋白 | 重组人类 NLRP3 蛋白
英文别名
AII/AVP | Angiotensin/vasopressin receptor AII/AVP like | Angiotensin/vasopressin receptor AII/AVP-like | C1orf7 | Caterpiller protein | CIAS 1 | CIAS1 | CLR1.1 | Cold autoinflammatory syndrome 1 | Cold autoinflammatory syndrome 1 protein | Cryopyrin | Fa
30.4 & 57.3 kDa, under reducing conditions; 28.8 & 55.0 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 50mM Tris, 500mM NaCl, pH 8.8
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human NLRP3 Protein (rp183755) - SDS-PAGE 2 μg/lane of Recombinant Human NLRP3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 30.4 & 57.3 kDa under reducing conditions and 28.8 & 55.0 kDa under non-reducing conditions.
ZJ24F0708022
危险品化学品经营许可证（带存储）