Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors. Human IFNA2 was originally cloned in the early ‘80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology. Structurally, type I IFNs belong to the class of five helical bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds. Mature human IFNA6, also known as IFN-alpha K, shares 56% aa sequence identity with mouse IFNA6. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA6 has been shown to be a strong inducer of IFN-stimulated genes and anti-viral protection. IFNA6 displays high potency against metapneumovirus and inhibition of HIV infection.
16.7-19.6 kDa, under reducing conditions; 17.9 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, 5% Trehalose, 5% Mannitol, pH 7.4
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月；复溶后建议分装，避免反复冻融.
图片
Recombinant Human IFN-alpha 6/IFNA6 Protein (rp222556) - SDS-PAGE
3 μg/lane of Recombinant Human IFN-alpha 6/IFNA6 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 16.7-19.6 kDa under reducing conditions and 17.9 kDa under non-reducing conditions.
ZJ25F1129659
危险品化学品经营许可证（带存储）