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辛可宁

4篇引用文献
  • ≥98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
C106926-5g
 5g 现货 Stock Image
C106926-25g
 25g 现货 Stock Image
C106926-100g
 100g 期货 Stock Image
C106926-500g
 500g 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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Anti-infection (2827) Apoptosis (1468) Parasite (431) 六元杂环化合物 (1702) 吡啶类 (1247)
main product photo

基本描述

别名 弱金鸡纳碱
英文别名 (S)-quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol | GNF-Pf-3189 | NCGC00262542-03 | .alpha.-Quinidine | NSC 6176 | HMS2096J18 | Prestwick3_000608 | LA40221 | (8R,9S)-Cinchonine | UNII-V43X79NZCD | 2-Quinuclidinemethanol, .alpha.-4-quinolyl-5-v
规格或纯度 ≥98%
英文名称 (+)-Cinchonine
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

不溶于水。

AI解读

关联靶点（人）

ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC2A1 Tchem Glucose transporter (14755 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A498 (42825 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Huh-7 (12904 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-4 (44535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-295 (48000 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SN12C (47755 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TK-10 (45540 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-257 (46019 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-62 (47335 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
WI-38 (2654 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
786-0 (47912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI/ADR-RES (33767 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EKVX (44102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H322M (45589 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hs-578T (29457 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-268 (49410 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IGROV-1 (47897 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LOX IMVI (44321 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HOP-62 (47048 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ht1 Hexose transporter 1 (14071 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania mexicana mexicana (27 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504756027
EC号 204-234-6
分子类型 小分子
IUPAC Name (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
INCHI InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1
InChi Key KMPWYEUPVWOPIM-QAMTZSDWSA-N
Canonical SMILES C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
Isomeric SMILES C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@H](C3=CC=NC4=CC=CC=C34)O
WGK Germany 3
RTECS GD3500000
PubChem CID 90454
分子量 294.39
Beilstein号 89689
Reaxy-Rn 89689

化学和物理性质

溶解性 不溶于水；微溶于酒精；微溶于乙醚、氯仿
密度 1.2
敏感性 对光敏感
比旋光度 223 ° (C=0.5, EtOH)
熔点 256-266°C
分子量 294.400 g/mol
XLogP3 2.700
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 294.173 Da
单同位素质量Monoisotopic Mass 294.173 Da
拓扑极表面积Topological Polar Surface Area 36.400 Ų
重原子数Heavy Atom Count 22
形式电荷Formal Charge 0
复杂度Complexity 412.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 4
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H302: 吞食有害

H317: 可能引起皮肤过敏反应

H332: 吸入有害
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P272: 被污染的工作服不允许离开工作场所

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P330: 漱口

P301+P317: 如果被吞咽：请寻求医疗帮助。

P317: 寻求紧急医疗救助。
WGK Germany 3
RTECS GD3500000
Reaxy-Rn 89689
Merck Index 2287
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

技术规格说明书

Loss on drying 0-1（%）
Purity(HPLC)（~85%Cinchonine+~15% dihydrocinchonine） 98-100（%）
Quinidine 0-3（%）
Specific Rotation[a]20/D(c=0.5 in EtOH) 218-228（°）
Sulfate Ash 0-0.1（%）
Quinine 0-3（%）
Purity(NonaqueousTitration) 98-100（%）
Appearance（C106926) white to grey powder or crystals
Proton NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到10个结果

批号(Lot Number) 证书类型 日期 货号
G2101372 分析证书 25-04-03 C106926
G2416568 分析证书 24-04-27 C106926
F2216161 分析证书 22-02-24 C106926
F2216248 分析证书 22-02-24 C106926
F2216249 分析证书 22-02-24 C106926
F2216250 分析证书 22-02-24 C106926
H2309591 分析证书 22-02-24 C106926
K2425024 分析证书 22-02-24 C106926
L2321176 分析证书 22-02-24 C106926
A2220063 分析证书 22-01-22 C106926

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yu-Shan Zhang, Xi Qiao, Chao Guo, Xiao-Li Zhang, Bin Hu, Xin Zhao, Li-Jiao Deng, Xiao-Chan Zhu, Yi Zhang, Yun-Feng Liu.  (2023)  Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis.  Drug Design Development and Therapy,  [PMID:37197367] [10.2147/DDDT.S404055]
2. Zhi-Yuan Zhang, Li-Li Rui, Ya-Li Lin, Hui-Dan Zhang, Ji-Ming Ou, Jian-Feng He, Quan-Zhou Wu.  (2021)  Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract.  POLYMER INTERNATIONAL,  70  (9): (1344-1355).  [10.1002/pi.6205]
3. Yuan Tan, Lijing Jing, Yonghong Ding, Tianxin Wei.  (2015)  A novel double-layer molecularly imprinted polymer film based surface plasmon resonance for determination of testosterone in aqueous media.  APPLIED SURFACE SCIENCE,  342  (84).  [10.1016/j.apsusc.2015.03.031]
4. Li Liu, Xuecai Tan, Xiaoxue Fang, Yuexin Sun, Fuhou Lei, Zaiyin Huang.  (2012)  Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic-Type Acids as Cross-Linker for the Determination of Quinine.  ELECTROANALYSIS,  24  (7): (1647-1654).  [10.1002/elan.201200085]

参考文献

1. Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S et al..  (2010)  Thousands of chemical starting points for antimalarial lead identification..  Nature,  465  (7296): (305-10).  [PMID:20485427] [10.1021/op500134e]
2. Olaf Kuhlmann,Hans-Stefan Hofmann,Sylvana P Müller,Michael Weiss.  (2003-07-11)  Pharmacokinetics of idarubicin in the isolated perfused rat lung: effect of cinchonine and rutin..  Anti-cancer drugs,  14  ((6)): (411-416).  [PMID:12853881]
3. Xianhong Wen,Ziyang Liu,Tianqiang Zhu,Miaoqin Zhu,Kezhi Jiang,Qiaoqiao Huang.  (2004-06-24)  Evidence for the 2:1 molecular recognition and inclusion behaviour between beta- and gamma-cyclodextrins and cinchonine..  Bioorganic chemistry,  32  ((4)): (223-233).  [PMID:15210337]
4. Chensong Pan,Songyun Xu,Hanfa Zou,Zhong Guo,Yu Zhang,Baochuan Guo.  (2005-02-08)  Carbon nanotubes as adsorbent of solid-phase extraction and matrix for laser desorption/ionization mass spectrometry..  Journal of the American Society for Mass Spectrometry,  16  ((2)): (263-270).  [PMID:15694776]
5. Qing-Min Xu,Dong Wang,Mei-Juan Han,Li-Jun Wan,Chun-Li Bai.  (2005-05-07)  Direct STM investigation of cinchona alkaloid adsorption on Cu(III)..  Langmuir : the ACS journal of surfaces and colloids,  20  ((8)): (3006-3010).  [PMID:15875820]
6. A Louise Tillman,Jinxing Ye,Darren J Dixon.  (2006-03-07)  Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative..  Chemical communications (Cambridge, England),  ((11)(11)): (1191-1193).  [PMID:16518487]
7. Iwona Tesarowicz,Barbara J Oleksyn,Wojciech Nitek.  (2006-12-08)  Crystal and molecular structures of trichloro-cobalt(II) complexes of epiquinine, epiquinidine, and epidihydrocinchonine..  Chirality,  19  ((2)): (152-161).  [PMID:17152047]
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12. Jian Zhang,Shumei Chen,Tao Wu,Pingyun Feng,Xianhui Bu.  (2008-09-09)  Homochiral crystallization of microporous framework materials from achiral precursors by chiral catalysis..  Journal of the American Chemical Society,  130  ((39)): (12882-12883).  [PMID:18774816]
13. Jeremiah P Malerich,Koji Hagihara,Viresh H Rawal.  (2008-10-14)  Chiral squaramide derivatives are excellent hydrogen bond donor catalysts..  Journal of the American Chemical Society,  130  ((44)): (14416-14417).  [PMID:18847268]
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15. Aleksandra Wesełucha-Birczyńska,Barbara J Oleksyn,Joanna Watroba.  (2009-11-04)  Channel-like crystal structure of cinchoninium L-O-phosphoserine salt dihydrate..  Chirality,  22  ((6)): (557-564).  [PMID:19885820]
16. Yueqi Liu,Kaori Hoshina,Jun Haginaka.  (2010-02-16)  Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization..  Talanta,  80  ((5)): (1713-1718).  [PMID:20152401]
17. Francisco J Prado-Prado,Xerardo García-Mera,Humberto González-Díaz.  (2010-02-27)  Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species..  Bioorganic & medicinal chemistry,  18  ((6)): (2225-2231).  [PMID:20185316]
18. Edinson Lucumi,Claire Darling,Hyunil Jo,Andrew D Napper,Rajesh Chandramohanadas,Nicholas Fisher,Alison E Shone,Huiyan Jing,Stephen A Ward,Giancarlo A Biagini,William F DeGrado,Scott L Diamond,Doron C Greenbaum.  (2010-06-16)  Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay..  Antimicrobial agents and chemotherapy,  54  ((9)): (3597-3604).  [PMID:20547797]
19. Zbigniew Karczmarzyk,Teodozja M Lipińska,Waldemar Wysocki,Monika Denisiuk,Katarzyna Piechocka.  (2011-09-02)  Tosyl esters of cinchonidine and cinchonine alkaloids: the structure-reactivity relationship in the hydrolysis to 9-epibases..  Acta crystallographica. Section C, Crystal structure communications,  67  ((Pt 9)): (o346-o349).  [PMID:21881184]
20. Qing Gu,Shu-Li You.  (2011-09-15)  Desymmetrization of cyclohexadienones via asymmetric Michael reaction catalyzed by cinchonine-derived urea..  Organic letters,  13  ((19)): (5192-5195).  [PMID:21913734]
21. Yu-Hua Liao,Xiong-Li Liu,Zhi-Jun Wu,Xi-Lin Du,Xiao-Mei Zhang,Wei-Cheng Yuan.  (2012-04-14)  Organocatalytic asymmetric conjugate addition of 3-monosubstituted oxindoles to (E)-1,4-diaryl-2-buten-1,4-diones: a strategy for the indirect enantioselective furanylation and pyrrolylation of 3-alkyloxindoles..  Chemistry (Weinheim an der Bergstrasse, Germany),  18  ((21)): (6679-6687).  [PMID:22499157]
22. Rishi Ranjan Pandey,Akansha Srivastava,Richa Malasoni,Arshi Naqvi,Ashish Jain,Jagdamba Prasad Maikhuri,Sarvesh Paliwal,Gopal Gupta,Anil Kumar Dwivedi.  (2012-08-01)  Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents..  Bioorganic & medicinal chemistry letters,  22  ((17)): (5735-5738).  [PMID:22846917]
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