JavaScript 似乎在您的浏览器中禁用。 在我们的网站上获得最佳体验，请务必打开 Javascript 在您的浏览器。

为了获得访问"阿拉丁铁蛋"实时聊天框的流畅支持体验，建议您使用Chrome浏览器或选择360浏览器极速模式(如何切换极速模式?)，感谢您选择我们！

切换导航

我的购物车

搜索

菜单

账号

辛伐他汀

HMG-CoA还原酶抑制剂

规格或纯度: ≥97% (HPLC)

CAS编号: 79902-63-9
分子式: C₂₅H₃₈O₅
分子量: 418.57
MDL号: MFCD00072007
PubChem编号: 54454

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
S129538-250mg	250mg	现货
S129538-1g	1g	现货
S129538-5g	5g	现货
S129538-10g	10g	现货
S129538-25g	25g	现货
S129538-100g	100g	现货

查看相关系列

hydroxymethylglutaryl-CoA reductase Inhibitor

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	舒降脂\|塞瓦停\|西伐斯汀
英文别名	simvastatin\|79902-63-9\|Zocor\|Synvinolin\|Sinvacor\|Denan\|Lipex\|MK-733\|Sivastin\|Lodales\|Cholestat\|Simvastatine\|Colemin\|Medipo\|Pantok\|Simovil\|Labistatin\|Simvastatina\|Simvastatinum\|Velostatin\|Coledis\|Corolin\|Nivelipol\|Rendapid\|Vasotenal\|Zorced\|Rechol\|Zocord\|Si
规格或纯度	≥97% (HPLC)
英文名称	Simvastatin
生化机理	Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies sμggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 μM).HMG-CoA reductase inhibitor. Hypolipidemic, decreasing low denisty lipoprotein (LDL) levels. Implicated in a multitude of biological functions, demonstrating anticancer and anti-inflammatory properties.
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	250mg卖完停产，不再备货如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	产品介绍：辛伐他汀是药物前体。辛伐他汀是洛伐他汀的半合成衍生物/类似物。辛伐他汀不溶于水，但可溶于极性有机溶剂。产品用途：辛伐他汀已用于： • 用于 HMG CoA还原酶(HMGCR)的抑制剂 • 研究其对上皮间质转化(EMT)以及肺腺癌患者预后的影响 • 体内研究检验其对脑肿瘤−启动细胞(BTIC)活力和细胞增殖的影响 • 研究三磷酸腺苷(ATP)-结合盒转运蛋白A7在Jurkat细胞吞噬作用中的作用 • 研究其对小鼠内皮功能障碍和炎症的影响 Product Description Simvastatin is a prodrug. Simvastatin is a semisynthetic derivative/analog of lovastatin. Simvastatin is insoluble in water but is soluble in polar organic solvents. Product Application Simvastatin has been used: • as an inhibitor of HMG CoA reductase (HMGCR) • to study its effects on epithelial to mesenchymal transition (EMT) and the prognosis of patients with lung adenocarcinoma • in in vivo studies to test its effect on brain tumor−initiating cells (BTIC) viability and cell proliferation • to study the role of adenosine triphosphate (ATP)-binding cassette transporter A7 in phagocytosis of Jurkat cells • to study the effect on endothelial dysfunction and inflammation in mice

产品属性

ALogP	4.7

名称和标识符

IUPAC Name	[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
INCHI	InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChi Key	RYMZZMVNJRMUDD-HGQWONQESA-N
Canonical SMILES	CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
Isomeric SMILES	CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
WGK Germany	2
RTECS	EK7798000
PubChem CID	54454
分子量	418.57
Reaxy-Rn	4768037

数据库链接

ChEMBL Ligand	CHEMBL1064
PubChem CID	54454
CAS Registry No.	79902-63-9
ChEBI	CHEBI:9150
DrugBank Ligand	DB00641
Wikipedia	Simvastatin
PEP	simvastatin
DrugCentral Ligand	2445

化学和物理性质

溶解性	Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol.
敏感性	对湿度和空气敏感
比旋光度	293° (C=1,CH3CN)
熔点	134°C

安全和危险性（GHS）

象形图	Environmental Hazard Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H410: Very toxic to aquatic life with long lasting effects H362: May cause harm to breast-fed children
预防措施声明	P273,P280,P302+P352,P321,P501,P264,P260,P270,P362+P364,P391,P263,P203,P318,P332+P317
WGK Germany	2
RTECS	EK7798000
Reaxy-Rn	4768037
Merck Index	8539
个人防护装备	Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

可替换产品

产品问答

登录提交问题

查看全部

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Denys A et al.. (2022) Binge Ethanol Exposure in Mice Represses Expression of Genes Involved in Osteoblast Function and Induces Expression of Genes Involved in Osteoclast Differentiation Independently of Endogenous Catalase.. Toxicol Sci, 185 (2): (232-245). [PMID:34755883]
2. Paškeviciute M & Petrikaite V. (2017) Differences of statin activity in 2D and 3D pancreatic cancer cell cultures.. Drug Des Devel Ther, 11 (): (3273-3280). [PMID:29180851]
3. Wang KC et al.. (2016) Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.. Proc Natl Acad Sci U S A, 113 (41): (11525-11530). [PMID:27671657]
4. Peng Y et al.. (2017) Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.. J Cancer, 8 (9): (1655-1664). [PMID:28775785]
5. Dai B et al.. (2021) Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss.. Bioact Mater, 6 (8): (2511-2522). [PMID:33665494]