计算溶液所需的质量、体积或浓度。
ARGX-117 (anti-Complement C2) (Ab190121) - ELISA
Immobilized Human Complement C2 Protein at 2.0 μg/mL can bind ARGX-117 (anti-Complement C2) (Ab190121) with the EC
₅₀
of 41.04 ng/mL.
ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
ARGX-117 (anti-Complement C2) 是一种针对补体 C2 的人源化抑制性单克隆抗体。ARGX-117 (anti-Complement C2) 通过与 C2 的 Sushi-2 结构域结合,防止 C3 原转化酶的形成,并抑制 C3 激活上游的经典途径和凝集素途径激活。ARGX-117 (anti-Complement C2) 表现出 pH 和钙依赖性靶标结合。ARGX-117 (anti-Complement C2) 在自身免疫性溶血性贫血和抗体介导的器官移植排斥的体外模型中预防补体介导的细胞毒性。
ARGX-117 (anti-Complement C2) a humanized inhibitory monoclonal antibody against complement C2. ARGX-117 (anti-Complement C2) prevents the formation of the C3 proconvertase and inhibits classical and lectin pathway activation upstream of C3 activation through binding to the Sushi-2 domain of C2. ARGX-117 (anti-Complement C2) exhibits pH- and calcium-dependent target binding. ARGX-117 (anti-Complement C2) prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
ARGX-117 (anti-Complement C2) (Ab190121) - ELISA
Immobilized Human Complement C2 Protein at 2.0 μg/mL can bind ARGX-117 (anti-Complement C2) (Ab190121) with the EC
₅₀
of 41.04 ng/mL.
ARGX-117 (anti-Complement C2) (Ab190121) - SEC
The purity of ARGX-117 (anti-Complement C2) (Ab190121) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab190121 | |
| 分析证书 | Ab190121 | |
| 分析证书 | Ab190121 |
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