无气味。微带酸味。在干燥空气中稳定，在潮湿空气中逐渐水解成水杨酸和乙酸。遇沸水或溶于氢氧化钠碱溶液和碳酸碱溶液中全部分解。溶于乙醇、乙醚和氯仿。检定锰。有机合成。乙酰水杨酸靠抑制环化加氧酶（cyclooxygenase，前列腺素H合成酶)阻止前列腺索的生产，特别是针对COX-1同种型有很高的选择性。其抗血栓效果就是由于抑制了血小板中起凝血和血小板凝聚作用的COX-1。

Information

Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversibleCOX1andCOX2inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin inducesautophag
In vitro

Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

Acetylsalicylic acid, ASA | 2-(acetyloxy)-benzoic acid

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Aspirin (NSC 27223)

生化机理

阿司匹林（NSC 27223，乙酰水杨酸，ASA）是一种水杨酸盐，也是不可逆的 COX1 和 COX2 抑制剂，可用作镇痛剂来缓解轻微疼痛，用作解热剂来退烧，还可用作消炎药。阿司匹林可诱导自噬和刺激有丝分裂。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

环氧化酶抑制剂

名称和识别符

EC号

200-064-1

分子类型

小分子

Isomeric SMILES

CC(=O)OC1=CC=CC=C1C(=O)O

UN Number

2811

Packing Group

分子量

180.16

Beilstein号

779271

Reaxy-Rn

779271

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=779271&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

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✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

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产品规格和应用的快速参考摘要。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

产品属性

ALogP	1.2

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点击查看靶蛋白信息： PTGS1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

PTGS2 Tclin 前列腺素 G/H 合酶 2(Prostaglandin G/H synthase 2) (1 活性数据)

点击查看靶蛋白信息： PTGS2

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点击查看靶蛋白信息： ASIC3

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化学和物理性质

溶解性

Solubility (25°C) In vitro Ethanol: 7 mg/mL (33.45 mM); DMSO: 2 mg/mL (9.55 mM); Water: Insoluble;

闪点(℉)

446 °F

闪点(℃)

250℃

熔点

136-140°C

安全和危险性（GHS）

WGK Germany

RTECS

VO0700000

Class

6.1

Merck Index

851

个人防护装备

dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

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