计算溶液所需的质量、体积或浓度。
提供 ≥95% 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 7 篇同行评审文献引用。
序列:
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
生化机理:
淀粉样蛋白β蛋白片段1-42 (Aβ 1-42) 具有抗氧化及神经保护性质。淀粉样蛋白β蛋白的积累与阿尔兹海默症(AD)和唐氏综合症相关。Aβ 1-42可调节胆固醇的转运并可作为一种转录因子。它可能还具有抗炎及抗微生物的作用。
应用:
在阿尔茨海默症和唐氏综合症患者的大脑中发现了淀粉样蛋白β-蛋白的主要片段。
淀粉样蛋白β蛋白片段1-42已用于:
1. Aβ 1-42低聚体的制备
2. western blot分析
3. 免疫磁性降低(IMR)血浆Aβ42检测的干扰试验
4.研究白藜芦醇对Aβ 1-42诱导的空间学习、记忆和突触可塑性损害的影响
5. 研究Aβ在上皮细胞培养中的作用
Sequence:
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Biochemical mechanism:
Amyloid protein β Protein segment 1-42 (A β 1-42) It has antioxidant and neuroprotective properties. Amyloid protein β Protein accumulation is associated with Alzheimer's disease (AD) and Down syndrome. A β 1-42 regulates cholesterol transport and acts as a transcription factor. It may also have anti-inflammatory and antimicrobial effects.
Application:
Amyloid protein is found in the brain of patients with Alzheimer's disease and Down syndrome β- The main segment of the protein.
Amyloid protein β Protein fragments 1-42 have been used to:
1. A β Preparation of 1-42 oligomer
2. Western blot analysis
3. Immunomagnetic Reduction (IMR) Plasma A β 42 Detected interference test
4. Study the effect of resveratrol on A β 1-42 induced impairment of spatial learning, memory and synaptic plasticity
5. Study A β Role in epithelial cell culture
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 | |
| 分析证书 | A494432 |
| 1. Ling Zhu, Congyan Liu, Yang Wang, Xuanang Zhu, Lei Wu, Lvan Chen, Jing Zhou, Fan Wang. (2025) METTL3/IGF2BP2/IκBα axis participates in neuroinflammation in Alzheimer's disease by regulating M1/M2 polarization of microglia. NEUROCHEMISTRY INTERNATIONAL, [PMID:40107503] [10.1016/j.neuint.2025.105964] |
| 2. Qiang-Ming Li, Hui-Hui Han, Dan-Dan Zang, Xue-Qiang Zha, An Zhou, Feng-Yun Zhang, Jian-Ping Luo. (2024) Rapid Discovery of Aβ42 Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer’s Disease. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38362879] [10.1021/acs.jafc.3c08664] |
| 3. Shuhan Wang, Yaqi Yang, Jiahong Lin, Weishan Zhang, Cuizhu Yang, Runheng Zhang, Chang Zhou, Li Zhang, Xin Wang, Jing Liu, Xiaobao Jin, Yuxin Ma. (2025) Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:40032030] [10.1016/j.freeradbiomed.2025.02.047] |
| 4. Kai Wang, Shujie Zan, Jiachun Xu, Weiming Sun, Caixia Li, Wei Zhang, Daoyan Ni, Ruzhen Cheng, Lin Li, Zhen Yu, Linlin Zhang, Shuang Liu, Yuanwu Cui, Yulian Zhang. (2024) Yishen Huazhuo decoction regulates microglial polarization to reduce Alzheimer's disease-related neuroinflammation through TREM2. Heliyon, [PMID:39220981] [10.1016/j.heliyon.2024.e35800] |
| 5. Wang Yangyang, Li Siyu, Liang Xiao, Fan Jianing, Li Shijie, Zhou Fanlin, Li Xiaoju, Lai Mengmeng, Feng Dianmao, Li Yu. (2025) AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease. Alzheimers Research & Therapy, 17 (1): (1-22). [PMID:40490761] [10.1186/s13195-025-01771-1] |
| 6. Jialin Wu, Xiaonan Lu, Jienian Zhang, Shuaihan Wang, Zeyuan Lu, Yutong Han, Ruihan Yang, Yiliang Su, Cheng Tan, Dianqiu Huo, Yong U. Liu, Jian Sima. (2026) Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer’s pathology. Cell Reports, 45 (4): [PMID:41880326] [10.1016/j.celrep.2026.117193] |
| 7. Ma Ya-nan, Wang Zijie, Liang Yuchang, Tan Guoao, Hu Xiqi, Xia Ying. (2026) Olfactory Mucosa Mesenchymal Stem Cell–Derived Exosomes Enhance Microglia M2 Polarization via the FGFR1/PLCγ1 Axis to Alleviate Alzheimer’s Disease. MOLECULAR NEUROBIOLOGY, 63 (1): (518). [PMID:41874868] [10.1007/s12035-026-05797-w] |