NEF3 | NEF3neurofilament medium polypeptide | NEFM | Neurofilament 3 | neurofilament, medium polypeptide 150kDa | neurofilament, medium polypeptide | neurofilament-3 (150 kD medium) | NFM | NF-M | NF-M160 kDa neurofilament protein | 150kDa medium antibody
规格或纯度
见COA
生化机理
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
Post-translational: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function. Phosphorylated in the Head and Rod regions by the PKC kinase PKN1, leading to inhibit polymerization.