Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
宿主种属
兔(Rabbit)
特异性
24p3R
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),牛(Cow)
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SLC22A17.
24p3R Antibody (Ab086670) - Western Blot All lanes: 24p3R Antibody (Ab086670) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 57 kDa Observed band size: 57 kDa Exposure time: 71.2 s
ZJ24F1215662
危险品化学品经营许可证（带存储）