AGT | alpha-1 antiproteinase, antitrypsin | Angiotensin II | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Angiotensinogen | ANHU | Aogen | FLJ92595 | FLJ97926 | PAT | pre-angiotensinogen | serine (or cysteine) proteinase inhibitor | S
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Angiotensin-3 stimulates aldosterone release.
Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
宿主种属
兔(Rabbit)
特异性
AGT
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human Angiotensinogen (AA 50-100).
Recombinant Angiotensinogen Antibody (Ab088853) - Western Blot All lanes: Recombinant Angiotensinogen Antibody (Ab088853) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 52 kDa Observed band size: 47 kDa Exposure time: 100.0 s
ZJ25F0218725
危险品化学品经营许可证（带存储）