Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
宿主种属
兔(Rabbit)
特异性
APC
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human APC (AA 72-90)
Recombinant APC Antibody (Ab089133) - Western Blot All lanes: Recombinant APC Antibody (Ab089133) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/50000 dilution
Predicted band size: 312 kDa Observed band size: 176 kDa Exposure time: 54.9 s
Recombinant APC Antibody (Ab089133) - IF/CC Immunocytochemistry analysis of APC (green) in LNCaP using Recombinant APC Antibody (Ab089133), and DAPI(blue).
ZJ24F0102374
危险品化学品经营许可证（带存储）