Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.
Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
宿主种属
兔(Rabbit)
特异性
beta Catenin
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human beta Catenin (AA 663-681).
阳性对照
WB: HeLa, NIH/3T3 and C6 cell lysates. ICC/IF: 293T cells
Recombinant beta Catenin Antibody (Ab091079) - Western Blot All lanes: Recombinant beta Catenin Antibody (Ab091079) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 85 kDa Observed band size: 90 kDa Exposure time: 63.7 s
Recombinant beta Catenin Antibody (Ab091079) - IF/ICC Immunocytochemistry analysis of beta Catenin (green) in 293T using Recombinant beta Catenin Antibody (Ab091079), and cells were counterstained with DAPI (blue).
ZJ25F0318882
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