Rabbit anti Human BLNK Antibody, Recombinant, could be used for WB and so on.
规格
产品名称
Recombinant BLNK Antibody
别名
抗B-细胞连接蛋白(BLNK)单克隆抗体
英文别名
AGM4 antibody | B cell adapter containing SH2 domain protein antibody | B cell adapter containing Src homology 2 domain protein antibody | B cell adaptor containing SH2 domain antibody | B cell linker antibody | B cell linker protein antibody | B cell-spe
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
宿主种属
兔(Rabbit)
特异性
BLNK
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human BLNK (AA 401-456)
Recombinant BLNK Antibody (Ab091352) - Western Blot All lanes: Recombinant BLNK Antibody (Ab091352) at 1/3000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 50 kDa Observed band size: 37-75 kDa BLNK has been reported to have at least two isoforms, commonly pp68 and pp70, which are generated by alternative splicing of the human BLNK gene transcript. The phosphorylation of Syk is a key regulatory step in activating downstream signaling cascades. BLNK is an important target for studying B cell biology and related immunological processes (PMID: 9341187). Exposure time: 6.5 s
Recombinant BLNK Antibody (Ab091352) - Western Blot All lanes: Recombinant BLNK Antibody (Ab091352) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 50 kDa Observed band size: 75 kDa Exposure time: 27.5 s
ZJ25F0117205
危险品化学品经营许可证（带存储）