Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
宿主种属
兔(Rabbit)
特异性
CD105
种属反应性
人(Human),大鼠(Rat)
免疫原
A synthetic peptide derived from human CD105 (AA 1-200).
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant CD105 Antibody (Ab093666) - Western Blot All lanes: Recombinant CD105 Antibody (Ab093666) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 71 kDa Observed band size: 90 kDa Exposure time: 12.1 s Endoglin (CD105) is a homodimeric integral membrane glycoprotein composed of disulfide-linked subunits of 90 - 95 kDa (PMID: 12746487; 9872992).
Recombinant CD105 Antibody (Ab093666) - Western Blot All lanes: Recombinant CD105 Antibody (Ab093666) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 71 kDa Observed band size: 70 kDa Exposure time: 12.1 s
ZJ25F0217614
危险品化学品经营许可证（带存储）