被称为富集四跨蛋白微域(TERMs)的特化膜微域的结构成分,是受体聚集和信号传导的平台。因此参与多种生物功能,如细胞信号传导、粘附、迁移和蛋白质贩运。在激活单核细胞和 B 细胞中发挥作用。通过促进白细胞介素-7 受体/IL7R 信号转导,成为 B 细胞发育的重要调节因子。通过将 PKC 募集到质膜使其底物磷酸化,促进 B 细胞中的 BCR 信号传导。通过稳定 L-选择素/SELL 细胞表面的表达,在 B 细胞和 T 细胞向淋巴结归巢的过程中发挥重要作用。通过促进 TNF-α 和 LPS 信号传导,还可介导肝细胞和脂肪组织的代谢和炎症功能,而不受免疫系统的影响。
宿主种属
兔(Rabbit)
特异性
CD53
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human CD53 (AA 180-219).
Recombinant CD53 Antibody (Ab095014) - Western Blot All lanes: Recombinant CD53 Antibody (Ab095014) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 24 kDa Observed band size: 37 - 50 kDa The expression profile and molecular weight observed, which is due to glycosylation. Exposure time: 128.1 s
Recombinant CD53 Antibody (Ab095014) - Western Blot All lanes: Recombinant CD53 Antibody (Ab095014) at 1/1000 dilution Samples: Lysates at 10 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 24 kDa Observed band size: 49 kDa The expression profile and molecular weight observed, which is due to glycosylation Exposure time: 60.0 s