ExactAb™,已验证,重组 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Rabbit anti Human CDT2/RAMP Antibody, Recombinant, could be used for WB, IHC and so on.
Application:
WB:1/500-1/1000
IHC: 1/50-1/100
Protein Function:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Recombinant CDT2/RAMP Antibody (Ab095882) - Western Blot
All lanes: Recombinant CDT2/RAMP Antibody (Ab095882) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 79 kDa
Observed band size: 95 kDa
Exposure time: 30.0 s
Recombinant CDT2/RAMP Antibody (Ab095882) - IHC
Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Recombinant CDT2/RAMP Antibody (Ab095882). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
1/50 - 1/100
1/500-1/1000
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0708924 |
分析证书 | Ab095882 |
| ZJ24F0708925 |
分析证书 | Ab095882 |
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