Rabbit anti Human CLSTN1 Antibody, Recombinant, could be used for WB, IHC, ICC, IF and so on. Application: WB: 1/500-1/1000 IHC: 1/50-1/100 ICC/IF: 1/50-1/200 Protein Function: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.
规格
产品名称
Recombinant CLSTN1 Antibody
别名
CLSTN1抗体 | 老年痴呆相关类钙粘蛋白CS1抗体 | 重组CLSTN1抗体
英文别名
Alc alpha antibody | Alc-alpha antibody | Alcadein alpha 1 antibody | Alcadein alpha antibody | Alcadein-alpha antibody | alcalpha1 antibody | alcalpha2 antibody | Alzheimer related cadherin like protein antibody | Alzheimer-related cadherin-like protein
规格或纯度
ExactAb™, Validated, 重组, 1.2 mg/mL
宿主种属
兔(Rabbit)
特异性
CLSTN1
种属反应性
人(Human),仓鼠(Hamster),小鼠(Mouse)
免疫原
A synthetic peptide of human CLSTN1 (AA 969-981).
阳性对照
WB: HeLa, HEK293 and Jurkat cell lysates. IHC: Human colon cancer tissue. ICC/IF: HeLa cells.
Recombinant CLSTN1 Antibody (Ab096927) - Western Blot All lanes: Recombinant CLSTN1 Antibody (Ab096927) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 110 kDa Observed band size: 117 kDa Exposure time: 86.7 s
Recombinant CLSTN1 Antibody (Ab096927) - IF/ICC Immunocytochemistry analysis of CLSTN1 (green) in HeLa using Recombinant CLSTN1 Antibody (Ab096927) and DAPI (blue).
Recombinant CLSTN1 Antibody (Ab096927) - IHC Immunohistochemistry analysis of paraffin-embedded Human colon cancer using Recombinant CLSTN1 Antibody (Ab096927). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.