Differentially expressed in normal and neoplastic cells | Insulinoma glucagonoma clone 20 | Rab3 GDP/GTP exchange factor | Differentially expressed in normal and neoplastic cells antibody | FLJ35600 antibody | IG20antibody | Insulinoma glucagonoma clone 2
规格或纯度
重组, ExactAb™, 敲低验证, 已验证, 见COA
生化机理
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
宿主种属
兔(Rabbit)
特异性
DENN
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human DENN (AA 1611-1647).
Recombinant DENN Antibody (Ab099613) - Western Blot All lanes: Recombinant DENN Antibody (Ab099613) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 183 kDa Observed band size: 217 kDa Exposure time: 20.1 s
Recombinant DENN Antibody (Ab099613) - Western Blot All lanes: Recombinant DENN Antibody (Ab099613) at 1/1000 dilution Samples: Lysates at 20 µg per lane Predicted band size: 183 kDa Observed band size: 217 kDa
Recombinant DENN Antibody (Ab099613) - Western Blot All lanes use Recombinant DENN Antibody (Ab099613) at 1/1000 dilution for 1 hour at room temperature.
ZJ25F0117207
危险品化学品经营许可证（带存储）