Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).
宿主种属
兔(Rabbit)
特异性
DKC1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human DKC1 (AA 371-384)
阳性对照
WB: HeLa, MCF7 and U2OS cell lysates. IHC: Human breast cancer tissue. ICC/IF: K562 cells.
Recombinant DKC1/Dyskerin Antibody (Ab099931) - Western Blot All lanes: Recombinant DKC1/Dyskerin Antibody (Ab099931) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 58 kDa Observed band size: 45, 56 kDa Exposure time: 79.4 s
Recombinant DKC1/Dyskerin Antibody (Ab099931) - IF/ICC Immunocytochemistry analysis of DKC1 (green) in K562 using Recombinant DKC1/Dyskerin Antibody (Ab099931), and cells were counterstained with DAPI (blue).
Recombinant DKC1/Dyskerin Antibody (Ab099931) - IHC Immunohistochemistry analysis of paraffin-embedded Human breast cancer tissue using Recombinant DKC1/Dyskerin Antibody (Ab099931). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0303269
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