Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
宿主种属
兔(Rabbit)
特异性
DKK1
种属反应性
人(Human),大鼠(Rat)
免疫原
A synthetic peptide derived from human DKK1 (AA 204-266).
阳性对照
WB: A431, Jurkat, HeLa lysates. IHC: Human placenta tissue. IF/ICC: HeLa cells.
Recombinant DKK1 Antibody (Ab099940) - Western Blot All lanes: Recombinant DKK1 Antibody (Ab099940) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 29 kDa Observed band size: 37, 41, 50 kDa Exposure time: 24.9 s
Recombinant DKK1 Antibody (Ab099940) - IHC Immunohistochemistry analysis of paraffin-embedded Human placenta using Recombinant DKK1 Antibody (Ab099940). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F1114041
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