E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
宿主种属
兔(Rabbit)
特异性
UBR5
种属反应性
人(Human),小鼠(Mouse)
预测反应种属
大鼠(Rat)
免疫原
A synthetic peptide derived from human UBR5 (AA 1-54)
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant EDD Antibody (Ab100940) - Western Blot All lanes: Recombinant EDD Antibody (Ab100940) at 1/1000 dilution Samples: Lysates at 20 µg per lane
Predicted band size: 309 kDa Observed band size: 309 kDa
ZJ25F0318777
危险品化学品经营许可证（带存储）