In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
宿主种属
兔(Rabbit)
特异性
TSC1
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human Hamartin (AA 1100-1164).
Recombinant Hamartin Antibody (Ab106836) - Western Blot All lanes: Recombinant Hamartin Antibody (Ab106836) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 130 kDa Observed band size: 137 kDa Exposure time: 60.0 s