Glycine- and tyrosine-rich RNA-binding protein | GRY-RBP | hnRNP Q | NS1-associated protein 1 | Synaptotagmin-binding, cytoplasmic RNA-interacting protein | cytoplasmic RNA-interacting protein | dJ3J17.2 | Glycine and tyrosine rich RNA binding protein | G
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.
宿主种属
兔(Rabbit)
特异性
SYNCRIP
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human hnRNP Q (AA 603-616)
阳性对照
WB: K562, Hep G2 and C6 cell lysates. IHC: Human tonsil tissue. ICC/IF: HeLa cells
Recombinant hnRNP Q Antibody (Ab108467) - Western Blot All lanes: Recombinant hnRNP Q Antibody (Ab108467) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 70 kDa Observed band size: 72 kDa Exposure time: 8.5 s
Recombinant hnRNP Q Antibody (Ab108467) - Western Blot All lanes: Recombinant hnRNP Q Antibody (Ab108467) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 70 kDa Observed band size: 69 kDa Exposure time: 25.0 s
Recombinant hnRNP Q Antibody (Ab108467) - IF/ICC Immunocytochemistry analysis of hnRNP Q (green) in HeLa using Recombinant hnRNP Q Antibody (Ab108467), and cells were counterstained with DAPI (blue).
Recombinant hnRNP Q Antibody (Ab108467) - IHC Immunohistochemistry analysis of paraffin-embedded Human tonsil using Recombinant hnRNP Q Antibody (Ab108467). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0303886
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