Alpha type antiviral protein antibody | Antiviral protein, alpha-type antibody | Antiviral protein, beta-type antibody | AVP antibody | Beta type antiviral protein antibody | CRF2-1 antibody | Cytokine receptor class-II member 1 antibody | Cytokine recept
规格或纯度
ExactAb™, 已验证, 重组, 见COA
生化机理
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
宿主种属
兔(Rabbit)
特异性
Interferon alpha/beta receptor 1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Interferon alpha/beta receptor 1 (AA 100-150).
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
图片
Recombinant Interferon alpha/beta receptor 1 Antibody (Ab110955) - Western Blot All lanes: Recombinant Interferon alpha/beta receptor 1 Antibody (Ab110955) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 64 kDa Observed band size: 102 kDa Exposure time: 61.7 s
ZJ25F0622184
危险品化学品经营许可证（带存储）