Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
宿主种属
兔(Rabbit)
特异性
KCNC1
种属反应性
人(Human),兔(Rabbit),大鼠(Rat),小鼠(Mouse),牛(Cow)
免疫原
A KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Kv3.1.
阳性对照
WB: Hep G2 and SH-SY5Y cell lysates. IHC: Human brain tissue.
KCNC1 Antibody (Ab111830) - Western Blot All lanes: KCNC1 Antibody (Ab111830) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 57 kDa Observed band size: 61 kDa Exposure time: 13.6 s
KCNC1 Antibody (Ab111830) - IHC Immunohistochemical analysis of KCNC1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with KCNC1 Antibody (Ab111830) at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
ZJ25F0116640
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