Cytosolic inhibitor of Nrf2 antibody | INrf 2 antibody | INrf2 antibody | Keap 1 antibody | KEAP1 antibody | KEAP1_HUMAN antibody | Kelch like ECH associated protein 1 antibody | Kelch like family member 19 antibody | Kelch like protein 19antibody | Kelch
规格或纯度
重组, ExactAb™, 已验证, 高性能, 见COA
生化机理
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
宿主种属
兔(Rabbit)
特异性
KEAP1
种属反应性
人(Human),小鼠(Mouse)
免疫原
Recombinant protein of human Keap1 (AA 321-609)
阳性对照
WB: RAW 264.7, CTLL-2, HeLa, A549, MCF7 and Hep G2 cell lysates. IHC: Human breast cancer tissue.
Recombinant Keap1 Antibody (Ab111970) - Western Blot All lanes: Recombinant Keap1 Antibody (Ab111970) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 70 kDa Observed band size: 64 kDa Exposure time: 10.0 s
Recombinant Keap1 Antibody (Ab111970) - Western Blot All lanes: Recombinant Keap1 Antibody (Ab111970) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 70 kDa Observed band size: 64 kDa Exposure time: 20.0 s
Recombinant Keap1 Antibody (Ab111970) - IHC Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant Keap1 Antibody (Ab111970). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0102501
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