Rabbit anti Human Klotho Antibody, Recombinant, could be used for WB, IHC and so on. Application: WB: 1/500-1/1000 IHC: 1/50-1/100 Protein Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Recombinant Klotho Antibody (Ab112286) - Western Blot All lanes: Recombinant Klotho Antibody (Ab112286) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 116 kDa Observed band size: 68 kDa Exposure time: 100.0 s The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Recombinant Klotho Antibody (Ab112286) - Western Blot All lanes: Recombinant Klotho Antibody (Ab112286) at 1/1000 dilution Samples: Lysates at 20 µL (1/100 dilution) per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 116 kDa Observed band size: 58 kDa Exposure time: 10.0 s The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Recombinant Klotho Antibody (Ab112286) - IHC Immunohistochemistry analysis of paraffin-embedded Human fetal kidney using Recombinant Klotho Antibody (Ab112286). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
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