Rabbit anti Human Lamin A + Lamin C Antibody, Recombinant, could be used for WB, IHC, IF/ICC and so on.
规格
产品名称
Recombinant Lamin A + Lamin C Antibody
别名
核纤层蛋白A/C抗体 | 核纤层蛋白A/C重组单克隆抗体 | LMNA抗体 | LMNA重组单克隆抗体 | Lamin A + Lamin C抗体 | Lamin A + Lamin C重组单克隆抗体
英文别名
Lamin A + Lamin C | Lamin A + C | LMN1 | 70 kDa lamin | CDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LAMIN A | lamin A/C | LAMIN C | LDP1 | LFP | LGMD1B | LMN 1 | LMN A | LMN C | LMNA | LMNC | NY REN 32 antigen | PRO1 | LMNA_HUMAN | Pr
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
宿主种属
兔(Rabbit)
特异性
LMNA
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Lamin A/C (AA 25-40)
阳性对照
WB: HeLa, L929, NIH/3T3 and C6 cell lysates. IHC: Human breast cancer tissue. ICC/IF: HeLa cells.
Recombinant Lamin A + Lamin C Antibody (Ab112634) - Western Blot All lanes: Recombinant Lamin A + Lamin C Antibody (Ab112634) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 74 kDa Observed band size: 63, 71 kDa Exposure time: 2.2 s
Recombinant Lamin A + Lamin C Antibody (Ab112634) - IF/ICC Immunocytochemistry analysis of Lamin A/C (green) in HeLa using Recombinant Lamin A + Lamin C Antibody (Ab112634), and cells were counterstained with DAPI (blue).
Recombinant Lamin A + Lamin C Antibody (Ab112634) - IHC Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant Lamin A + Lamin C Antibody (Ab112634). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0506088
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