Rabbit anti Human LXR alpha Antibody, Recombinant, could be used for WB, IF/ICC and so on.
Application:
WB: 1/1000-1/2000 IF/ICC: 1/50-1/200
Protein Function:
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
规格
产品名称
Recombinant LXR alpha Antibody
别名
Anti-LXR alpha抗体 | LXR alpha抗体
英文别名
alpha | Liver X receptor alpha | liver X receptor-alpha | LXR alpha | LXRA | NR1H3 | Nuclear receptor subfamily 1 group H member 3 | nuclear receptor subfamily 1, group H, member 3 | oxysterols receptor LXR-alpha | RLD-1 | Liver X receptor alpha antibody
规格或纯度
重组, ExactAb™, 已验证, 见COA
宿主种属
兔(Rabbit)
特异性
NR1H3
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human NR1H3 (AA 50-100)
阳性对照
WB: Jurkat, Hep G2, MCF7, NIH/3T3 and C6 cell lysates. IF/ICC: HeLa cells.
Recombinant LXR alpha Antibody (Ab113743)- Western Blot All lanes: Recombinant LXR alpha Antibody (Ab113743) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution
Predicted band size: 50 kDa Observed band size: 48, 95 kDa Heterodimer of NR1H3 and RXR (retinoic acid receptor). Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with SIRT1 and this interaction is inhibited by CCAR2 (PMID: 25661920). Exposure time: 15.6 s
Recombinant LXR alpha Antibody (Ab113743) - IF/ICC Immunofluorescent analysis of HeLa cells, using Recombinant LXR alpha Antibody (Ab113743) at 1/50 dilution.
Recombinant LXR alpha Antibody (Ab113743) - IF/ICC Immunofluorescent analysis of HeLa cells, using Recombinant LXR alpha Antibody (Ab113743) at 1/50 dilution.
Recombinant LXR alpha Antibody (Ab113743) - IF/ICC Immunofluorescent analysis of HeLa cells, using Recombinant LXR alpha Antibody (Ab113743) at 1/150 dilution.
ZJ24F1114298
危险品化学品经营许可证（带存储）