Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
宿主种属
兔(Rabbit)
特异性
MFN2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Mitofusin 2 (AA 50-100)
阳性对照
WB: Hep G2, K562, NIH/3T3 and C6 cell lysates. IHC: Human breast carcinoma tissue. ICC/IF: HeLa cells.
Recombinant Mitofusin 2 Antibody (Ab115473) - Western Blot All lanes: Recombinant Mitofusin 2 Antibody (Ab115473) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution
Predicted band size: 86 kDa Observed band size: 54 kDa Exposure time: 24.1 s
Recombinant Mitofusin 2 Antibody (Ab115473) - IF/ICC Immunofluorescence analysis of Mitofusin 2 in HeLa cells using Recombinant Mitofusin 2 Antibody (Ab115473) (green), and cells were counterstained with DAPI (blue).
Recombinant Mitofusin 2 Antibody (Ab115473) - IHC Immunohistochemistry analysis of paraffin-embedded human breast carcinoma using Recombinant Mitofusin 2 Antibody (Ab115473). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F1215872
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