Mouse anti Human MUC1 Antibody, Recombinant (MyM1-MUC1), could be used for IHC and so on. Application IHC: 1/100-1/200 Protein Function The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Recombinant MUC1 Antibody (Ab116375) - IHC Immunohistochemistry analysis of paraffin-embedded human tonsil tissue labelling MUC1 with Recombinant MUC1 Antibody (Ab116375) at 1/100 dilution. The section was incubated with Ab116375 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.