PBS Only,已验证,无叠氮钠,无载体 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
2-8°C储存,禁止冷冻。低温运输,禁止冷冻 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Mouse anti Human MUC1/CD227 Antibody, Monoclonal (C595 (NCRC48)), could be used for in vivo administration in mouse xenograft models, IHC, ICC, IF, in vitro cell cytotoxicity assay, WB, Flow and so on.
Application:
in vivo administration in mouse xenograft models: Use at an assay dependent concentration.
IHC: Use at an assay dependent concentration.
ICC/IF: Use at an assay dependent concentration.
in vitro cell cytotoxicity assay: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.
Flow: Use at an assay dependent concentration.
Protein Function
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
MUC1/CD227 Mouse mAb (Ab116379) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling MUC1/CD227 (red) with MUC1/CD227 Mouse mAb (Ab116379) at 0.5 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F1113535 |
分析证书 | Ab116379 |
| ZJ24F1113536 |
分析证书 | Ab116379 |
| ZJ24F1113537 |
分析证书 | Ab116379 |
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