Rabbit anti Human PDGFC Antibody, Polyclonal, could be used for WB, IHC and so on. Application WB: 1/500-1/1000 IHC: 1/50 - 1/100 Protein Function Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.
规格
产品名称
PDGFC Antibody
别名
血小板源性生长因子C抗体
英文别名
FALLOTEIN | PDGFC | PDGF-C | platelet derived growth factor C | platelet-derived growth factor C | SCDGFSpinal cord-derived growth factor | secretory growth factor-like protein | VEGF-E | Fallotein antibody | hSCDGF antibody | PDGF-C antibody | PDGFC anti
规格或纯度
ExactAb™, Validated, Carrier Free, 1.0 mg/mL
宿主种属
兔(Rabbit)
特异性
PDGFC
种属反应性
人(Human),小鼠(Mouse)
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PDGFC.
阳性对照
WB: A549 and HEL cell lysates. IHC: Human colon cancer tissue.
PDGFC Antibody (Ab120901) - Western Blot All lanes: PDGFC Antibody (Ab120901) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab176443) at 1/20000 dilution Predicted band size: 39 kDa Observed band size: 18 kDa Exposure time: 20.0 s
PDGFC Antibody (Ab120901) - IHC Immunohistochemical analysis of PDGFC staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with PDGFC Antibody (Ab120901) at room temperature and detected using an HRP conjugated compact polymer system.