Rabbit anti Human PELP1 Antibody, Recombinant, could be used for WB, IHC, IF/ICC and so on.
规格
产品名称
Recombinant PELP1 Antibody
别名
HMX3蛋白抗体 | PELP1抗体 | 重组 PELP1 抗体 | HMX3蛋白抗体
英文别名
Modulator of non-genomic activity of estrogen receptor | Transcription factor HMX3 | MNAR | P160 | glutamic acid- and leucine-rich protein 1 antibody | HMX3 antibody | MNAR antibody | Modulator of non-genomic activity of estrogen receptor antibody | Modul
规格或纯度
重组,ExactAb™,已验证,见COA
生化机理
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K.
宿主种属
兔(Rabbit)
特异性
PELP1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human PELP1 (AA 1045-1058)
阳性对照
WB: HEK293, HeLa, MCF7, NIH/3T3 and C6 cell lysates. IHC: Human breast cancer tissue. ICC/IF: HeLa cells.
Recombinant PELP1 Antibody (Ab121178) - Western Blot All lanes: Recombinant PELP1 Antibody (Ab121178) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 120 kDa Observed band size: 169 kDa Exposure time: 56.9 s
Recombinant PELP1 Antibody (Ab121178) - IF/ICC Immunocytochemistry analysis of PELP1 (green) in HeLa using Recombinant PELP1 Antibody (Ab121178), and cells were counterstained with DAPI (blue).
Recombinant PELP1 Antibody (Ab121178) - IHC Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant PELP1 Antibody (Ab121178). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0404015
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