Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
宿主种属
兔(Rabbit)
特异性
PLK1
种属反应性
人(Human),大鼠(Rat)
免疫原
A synthetic peptide derived from human PLK1 (AA 455-474)
阳性对照
WB: Jurkat and Hep G2 cell lysates. ICC/IF: HeLa cells.
Recombinant PLK1 Antibody (Ab122369) - Western Blot All lanes: Recombinant PLK1 Antibody (Ab122369) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 68 kDa Observed band size: 65 kDa Exposure time: 149.4 s
Recombinant PLK1 Antibody (Ab122369) - IF/ICC Immunocytochemistry analysis of PLK1 (green) in HeLa using Recombinant PLK1 Antibody (Ab122369), and cells were counterstained with DAPI (blue).
ZJ24F0303421
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