CMT2Bantibody | PRO2706 antibody | PSN antibody | RAB7, member RAS oncogene family antibody | RAB7A antibody | RAB7A, member RAS oncogene family antibody | RAB7A_HUMAN antibody | Ras associated protein RAB7antibody | Ras related protein Rab7 antibody | Ra
规格或纯度
重组, ExactAb™, 已验证, 高性能, 见COA
生化机理
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.
宿主种属
兔(Rabbit)
特异性
RAB7
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human RAB7 (AA 185-200)
阳性对照
WB: Hep G2, MCF7, A431, A375, K562, HeLa, NIH/3T3 and C6 cell lysates. IHC: Mouse colon tissue. ICC/IF: HeLa cells.
Recombinant RAB7 Antibody (Ab124248) - Western Blot All lanes: Recombinant RAB7 Antibody (Ab124248) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 23 kDa Observed band size: 25 kDa Exposure time: 17.1 s
Recombinant RAB7 Antibody (Ab124248) - IF/ICC Immunocytochemistry analysis of RAB7(green) in HeLa cells using Recombinant RAB7 Antibody (Ab124248), and cells were counterstained with DAPI (blue).
Recombinant RAB7 Antibody (Ab124248) - IHC Immunohistochemistry analysis of paraffin-embedded mouse colon using Recombinant RAB7 Antibody (Ab124248). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0404021
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