RXRalpha | FLJ00280 | FLJ00318 | FLJ16020 | MGC102720 | NR2B1 | NR2B1FLJ16733 | Nuclear receptor subfamily 2 group B member 1 | retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | retinoid X receptor, alpha | RXR alpha | RXRA | FLJ00280 antibod
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
宿主种属
兔(Rabbit)
特异性
Retinoid X Receptor alpha/RXRA
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human Retinoid X Receptor alpha (AA 1-14)
Recombinant Retinoid X Receptor alpha/RXRA Antibody (Ab125125) - Western Blot All lanes: Recombinant Retinoid X Receptor alpha/RXRA Antibody (Ab125125) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 51 kDa Observed band size: 54 kDa Exposure time: 52.9 s
Recombinant Retinoid X Receptor alpha/RXRA Antibody (Ab125125) - IF/ICC Immunocytochemistry analysis of Retinoid X Receptor alpha (green) in MCF7 using Recombinant Retinoid X Receptor alpha/RXRA Antibody (Ab125125), and cells were counterstained with DAPI (blue).
ZJ24F1214870
危险品化学品经营许可证（带存储）