AML3|CCD|Acute myeloid leukemia 3 protein|CBFA1|CBF-alpha-1|CCD1|CCDAML3|CLCD|Core-binding factor subunit alpha-1|core-binding factor, runt domain, alpha subunit 1|ML3|oncogene AML-3|OSF2|OSF-2|osteoblast-specific transcription factor 2|PEA2-alpha A|PEBP2A|PEBP2aA|PEBP2-alpha A|polyomavirus enhancer-binding protein 2 alpha A subunit|runt domain, alpha subunit 1|runt related transcription factor 2|runt-related transcription factor 2|RUNX2|SL3/AKV core-binding factor alpha A subunit|SL3-3 enhancer factor 1 alpha A subunit|Acute myeloid leukemia 3 protein antibody|Alpha subunit 1 antibody|AML3 antibody|CBF alpha 1 antibody|CBF-alpha-1 antibody|CBFA1 antibody|CCD antibody|CCD1 antibody|Cleidocranial dysplasia 1 antibody|Core binding factor antibody|Core binding factor runt domain alpha subunit 1 antibody|Core binding factor subunit alpha 1 antibody|Core-binding factor subunit alpha-1 antibody|MGC120022 antibody|MGC120023 antibody|Oncogene AML 3 antibody|Oncogene AML-3 antibody|OSF 2 antibody|OSF-2 antibody|OSF2 antibody|Osteoblast specific transcription factor 2 antibody|Osteoblast-specific transcription factor 2 antibody|OTTHUMP00000016533 antibody|PEA2 alpha A antibody|PEA2-alpha A antibody|PEA2aA antibody|PEBP2 alpha A antibody|PEBP2-alpha A antibody|PEBP2A1 antibody|PEBP2aA antibody|PEBP2aA1 antibody|Polyomavirus enhancer binding protein 2 alpha A subunit antibody|Polyomavirus enhancer-binding protein 2 alpha A subunit antibody|Runt domain antibody|Runt related transcription factor 2 antibody|Runt-related transcription factor 2 antibody|RUNX2 antibody|SL3 3 enhancer factor 1 alpha A subunit antibody|SL3-3 enhancer factor 1 alpha A subunit antibody|SL3/AKV core binding factor alpha A subunit antibody|SL3/AKV core-binding factor alpha A subunit antibody|Oncogene AML-3|Osteoblast-specific transcription factor 2|Polyomavirus enhancer-binding protein 2 alpha A subunit|PEBP2A2 antibody
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
宿主种属
兔(Rabbit)
特异性
RUNX2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human RUNX2 (AA 300-450)
阳性对照
WB: MDA-MB-231 cell lysate. IHC: Human colon, Human Hodgkin's lymphoma tissue. IF/ICC: Saos-2 cells.
Recombinant RUNX2 Antibody (Ab126131) - Western Blot All lanes: Recombinant RUNX2 Antibody (Ab126131) at 1/1000 dilution Samples: Lysates at 10 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 57 kDa Observed band size: 59 kDa. The RUNX2 protein, also known as Core-binding factor 1, is a transcription factor that plays a crucial role in cell differentiation and skeletal development. Transcription factors with DNA-binding motifs influence migration resulting in the generation of multiple bands. Exposure time: 8.1 s
Recombinant RUNX2 Antibody (Ab126131) - IF/ICC Immunofluorescent analysis of Saos-2 cells, using Recombinant RUNX2 Antibody (Ab126131).
Recombinant RUNX2 Antibody (Ab126131) - IHC Immunohistochemical analysis of paraffin-embedded Human Hodgkin's lymphoma, using Recombinant RUNX2 Antibody (Ab126131) at 1/300 dilution.
Recombinant RUNX2 Antibody (Ab126131) - IHC Immunohistochemical analysis of paraffin-embedded human colon, using Recombinant RUNX2 Antibody (Ab126131).
ZJ24F0708450
危险品化学品经营许可证（带存储）