Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
宿主种属
兔(Rabbit)
特异性
RUNX2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human RUNX2 (AA 300-450)
阳性对照
WB: MDA-MB-231 cell lysate. IHC: Human colon, Human Hodgkin's lymphoma tissue. IF/ICC: Saos-2 cells.
Recombinant RUNX2 Antibody (Ab126131) - Western Blot All lanes: Recombinant RUNX2 Antibody (Ab126131) at 1/1000 dilution Samples: Lysates at 10 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 57 kDa Observed band size: 59 kDa. The RUNX2 protein, also known as Core-binding factor 1, is a transcription factor that plays a crucial role in cell differentiation and skeletal development. Transcription factors with DNA-binding motifs influence migration resulting in the generation of multiple bands. Exposure time: 8.1 s
Recombinant RUNX2 Antibody (Ab126131) - IF/ICC Immunofluorescent analysis of Saos-2 cells, using Recombinant RUNX2 Antibody (Ab126131).
Recombinant RUNX2 Antibody (Ab126131) - IHC Immunohistochemical analysis of paraffin-embedded Human Hodgkin's lymphoma, using Recombinant RUNX2 Antibody (Ab126131) at 1/300 dilution.
Recombinant RUNX2 Antibody (Ab126131) - IHC Immunohistochemical analysis of paraffin-embedded human colon, using Recombinant RUNX2 Antibody (Ab126131).
ZJ24F0708450
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