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S100A9 Mouse mAb

货号: Ab126262
COA
有货
级别和纯度: 见COA
应用
IHC, WB
宿主种属
小鼠(Mouse)
种属反应性
人(Human)
亚型
Mouse IgG2a
克隆号
OTI13E12
偶联
Unconjugated
★
规格
库存
价格
数量
10μl
Ab126262-10μl
期货 Stock Image
¥499.90
50μL
Ab126262-50μl
期货 Stock Image
¥1,299.90
100μL
Ab126262-100μl
期货 Stock Image
¥2,099.90
1ml
Ab126262-1ml
期货 Stock Image
¥13,999.90
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SDS
安全数据
COA
分析证书
Data Sheet
产品数据
Spec Sheet
规格说明
大包装询价 收藏夹
S100A9 Mouse mAb
概述 规格 储存与运输 应用 技术文档 高级数据 关联靶点（人） 作用机制 质检证书（CoA,COO,BSE/TSE 和分析图谱) 溶液计算器
🧪
为什么选择此级别

，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述


Mouse anti Human S100A9 Antibody, Monoclonal (OTI13E12), could be used for WB, IHC and so on.  

规格

产品名称
S100A9 Mouse mAb
别名
S100A9抗体 | S100A9单克隆抗体 | S100钙结合蛋白A9抗体
英文别名
Leukocyte L1 complex heavy chain antibody | 60B8AG antibody | CAGB antibody | Calgranulin B antibody | Calgranulin-B antibody | Calprotectin L1H subunit antibody | CFAG antibody | CGLB antibody | Cystic fibrosis antigen B antibody | L1AG antibody | Leukoc
规格或纯度
见COA
生化机理
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Participates also in regulatory T-cell differentiation together with CD69. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif.
宿主种属
小鼠(Mouse)
特异性
S100A9
种属反应性
人(Human)
免疫原
Recombinant full length protein of human S100A9 produced in SF9 cell.
阳性对照
WB: HEK293T transfected with pCMV6-ENTRY S100A9 cDNA for 48 hrs; MCF7 lysates. IHC: Human prostate, prostate carcinoma, lymphoma, tonsil tissues.
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
亚型
Rabbit IgG
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3.
防腐剂
0.02% Sodium azide
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
应用
应用名称
稀释比例
WB

1/2000

IHC

1/150

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点（人）
S100A9 Tchem 蛋白质S100-A9(Protein S100-A9) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
作用机制
作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
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