Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
宿主种属
兔(Rabbit)
特异性
SF3B3
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthesized peptide derived from human SF3B3 (AA 1150-1217)
Recombinant SF3B3 Antibody (Ab127281) - Western Blot All lanes: Recombinant SF3B3 Antibody (Ab127281) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 136 kDa Observed band size: 125 kDa SF3B3 is an RNA-binding protein that is part of the 17S U2 small nuclear ribonucleoprotein complex and plays a key role in the pre-mRNA splicing process (PubMed:10490618, 10882114, 12234937). The SF3B3 protein contains a RNA-binding motif, which affects its migration in Western blot experiments. Additionally, its expression pattern aligns with expectations. Exposure time: 88.6 s
ZJ25F0319258
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