0610042I06Rik antibody | EC 2.7.11.1 antibody | FLJ90748 antibody | KB 1458E12.1 antibody | Kinase responsive to stress 1 antibody | KRS1 antibody | Mammalian STE20 like protein kinase 2 antibody | Mammalian STE20-like protein kinase 2 antibody | Mammalia
规格或纯度
见COA
生化机理
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.
宿主种属
小鼠(Mouse)
特异性
STK3
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog),猴(Monkey)
免疫原
Recombinant protein of human STK3 (AA 1-491).
阳性对照
WB: HeLa, HT29, COS7, Jurkat, MDCK, MCF7, 3T3, Mouse brain, liver, spleen, Human brain, Testis lysates. IHC: Human colon, adenocarcinoma of colon, kidney, carcinoma of kidney, liver, lung, ovary, pancreas, endometrium tissue.