Rabbit anti Human TAP2 Antibody, Polyclonal, could be used for WB and so on.
规格
产品名称
TAP2 Antibody
别名
抗原肽转运蛋白2(TAP2)抗体 | 抗原肽转运蛋白2(TAP2)抗体
英文别名
APT2 | ATP-binding cassette sub-family B member 3 | EC 7.4.2.- | Peptide supply factor 2 | Peptide transporter involved in antigen processing 2 | Peptide transporter PSF2 | Peptide transporter TAP2 | PSF-2 | Really interesting new gene 11 protein | RING11
规格或纯度
见COA
生化机理
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
宿主种属
兔(Rabbit)
特异性
TAP2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human TAP2 (AA 182-232)