FLJ22139 antibody | p53 damage inducible nuclear protein 1 antibody | p53 dependent damage inducible nuclear protein 1 antibody | p53 inducible nuclear protein 1 antibody | p53 inducible p53DINP1 antibody | p53-dependent damage-inducible nuclear protein 1
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
宿主种属
兔(Rabbit)
特异性
TP53INP1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human p53 DINP1 (AA 100-168)
Recombinant TP53INP1 Antibody (Ab132038) - Western Blot All lanes: Recombinant TP53INP1 Antibody (Ab132038) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) at 1/20000 dilution Predicted band size: 27 kDa Observed band size: 31 kDa Exposure time: 100.0 s
ZJ24F1012655
危险品化学品经营许可证（带存储）