Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
宿主种属
兔(Rabbit)
特异性
VCAM1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human VCAM1 (AA 700-739).
阳性对照
WB: NIH/3T3, HUVEC (treated or untreated with hTNFα) cell lysates. IHC: Human tonsil tissue. ICC/IF: K562 cells.
VCAM1 Antibody (Ab133968) - Western Blot All lanes: VCAM1 Antibody (Ab133968) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 81 kDa Observed band size: 103 kDa Exposure time: 52.9 s
VCAM1 Antibody (Ab133968) - Western Blot All lanes: VCAM1 Antibody (Ab133968) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 81 kDa Observed band size: 90 kDa Exposure time: 15.9 s
VCAM1 Antibody (Ab133968) - IF/ICC Immunofluorescence analysis of VCAM1 in K562 using VCAM1 Antibody (Ab133968), and cells were counterstained with DAPI (blue).
VCAM1 Antibody (Ab133968) - IHC Immunohistochemistry analysis of paraffin-embedded Human tonsil using VCAM1 Antibody (Ab133968). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ25F0521533
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