BP-8 | CBF-A | CSDA2 | CSDB | DBPB | EFI-A | MDR-NF1 | NSEP-1 | NSEP1 | YB-1 | YB1 | BP 8 antibody | CBF-A antibody | CCAAT binding transcription factor I subunit A antibody | CCAAT-binding transcription factor I subunit A antibody | CSDA2 antibody | CSDB
规格或纯度
重组, ExactAb™, 已验证, 见COA
生化机理
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
宿主种属
兔(Rabbit)
特异性
YB1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human YBX1 (AA 280-324).
阳性对照
WB: HeLa, Hep G2, MCF7, NIH/3T3 and C6 cell lysates. IHC: Human kidney tissue. IF/ICC: HeLa, MCF7 cells.
Recombinant YB1 Antibody (Ab134994) - Western Blot All lanes: Recombinant YB1 Antibody (Ab134994) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 36 kDa Observed band size: 47 kDa Exposure time: 4.5 s
Recombinant YB1 Antibody (Ab134994) - Western Blot All lanes: Recombinant YB1 Antibody (Ab134994) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 36 kDa Observed band size: 47 kDa Exposure time: 8.5 s
Recombinant YB1 Antibody (Ab134994) - IHC Immunohistochemical analysis of paraffin-embedded human kidney, using Recombinant YB1 Antibody (Ab134994).
Recombinant YB1 Antibody (Ab134994) - IF/ICC Immunofluorescent analysis of HeLa cells, using the Recombinant YB1 Antibody (Ab134994) at 1/50 dilution.
Recombinant YB1 Antibody (Ab134994) - IF/ICC Immunofluorescent analysis of HeLa cells, using the Recombinant YB1 Antibody (Ab134994) at 1/50 dilution.
Recombinant YB1 Antibody (Ab134994) - IF/ICC Immunofluorescent analysis of HeLa cells, using the Recombinant YB1 Antibody (Ab134994) at 1/100 dilution.
Recombinant YB1 Antibody (Ab134994) - IF/ICC Immunofluorescent analysis of MCF7 cells, using the Recombinant YB1 Antibody (Ab134994).
ZJ25F0725030
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